The Extrahepatic siRNA Targeting group is looking for a highly motivated and talented cell biologist with strong expertise in cell biology and functional genomics. The ideal candidate will have a deep knowledge of cell surface receptor biology, endocytosis and recycling to cell surface. You will be responsible for investigating mechanistic aspects of in vivo siRNA delivery by cell surface receptors and their cognate ligands.

About the Role:

Internal Job Title: Principal Scientist II

Position location: San Diego, CA, onsite

The Extrahepatic siRNA Targeting group is looking for a highly motivated and talented cell biologist with strong expertise in cell biology and functional genomics. The ideal candidate will have a deep knowledge of cell surface receptor biology, endocytosis and recycling to cell surface. You will be responsible for investigating mechanistic aspects of in vivo siRNA delivery by cell surface receptors and their cognate ligands

Your responsibilities include, but are not limited to:

• Candidates should have extensive experience in the area of cell surface receptor in vivo biology with focus on receptor endocytosis and recycling
• Candidates should have leadership or managerial experience
• Prior experience with drug discovery is a plus
• Lead and participate in research efforts to build mechanistic understanding of extrahepatic siRNA delivery by novel cell surface receptors and their cognate ligands
• Stay up-to-date with the latest advancements in relevant assay technologies
• Initiate, lead and contribute to interdisciplinary research programs in a highly collaborative and matrixed manner across internal groups and with external partners
• Concise/accurate review and interpretation of technical data
• Present scientific and technical work
• Contribute to maintaining a safe laboratory environment and quality work practices
• Other related duties as assigned

Minimum requirements:

• PhD in cell biology or related field, with 5+ years of relevant experience, preferably in industry.   Candidates in academic staff/faculty positions (i.e. Assistant Professor, Director of Research, etc.) are also encouraged to apply 
• Extensive knowledge and hands on experience of mammalian receptor biology
• Experience with diverse cell biology methods including immunofluorescence microscopy, flow cytometry, etc.
• Ability to function in cross-functional teams, overcome challenges, develop and implement effective strategies and quickly adapt to new responsibilities
• Strong organizational and time management skills with excellent communication, both written and verbal
• Strong publication and external presentation record is preferred

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: http://www.novartis.com/about/strategy/people-and-culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: http://www.novartis.com/careers/benefits-rewards

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $114,100 to $211,900/year; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: http://talentnetwork.novartis.com/network